The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer.
作者： Yoon Yang Jung , Yu Kyung Lee , Ja Seung Koo
DOI: 10.1517/14728222.2016.1085971
关键词: Programmed cell death 、 Tumor progression 、 Cell 、 Autophagy 、 Internal medicine 、 Oncology 、 Interactome 、 Carcinogenesis 、 Cancer 、 Breast cancer 、 Medicine
摘要: Introduction: Beclin 1 plays a crucial role in autophagy via the interactome, and is involved various biological processes such as protein sorting, chemokinesis, cell death. Via these biologic functions, contributes to both tumor suppression progression.Areas covered: key function on homeostasis affects tumorigenesis. In this review, detailing up-to-date knowledge tumorigenic of 1, its implication breast cancer, utility cancer-specific drug target discussed.Expert opinion: Because expressed cancer cells, could be unique, effective for prevention treatment cancer. However, expression varies according molecular subtypes, progression; therefore, decision using inducer or inhibitor should made based stag...
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