The mutagenic activity of agaritine--a constituent of the cultivated mushroom Agaricus bisporus--and its derivatives detected with the Salmonella/mammalian microsome assay (Ames Test).
作者： Urs Fredrich , B�atrice Fischer , J�rg L�thy , Doris Hann , Christian Schlatter
DOI: 10.1007/BF01041921
关键词: Mushroom 、 Chemistry 、 Metabolite 、 Ames test 、 Agaritine 、 Agaricus 、 Enterobacteriaceae 、 Agaricus bisporus 、 Microsome 、 Biochemistry
摘要: Purified agaritine (N'-(gamma-L(+)-glutamyl)-p-hydroxymethylphenylhydrazine) isolated from Agaricus bisporus, p-hydrazinobenzoic acid (its presumptive precursor) and some agaritine-degradation products were tested for mutagenic activity with the Salmonella/mammalian microsome assay (Ames test). Consistent literature, showed a distinct direct-acting mutagenicity strain TA1537 (30 revertants/mumol) TA97. Incubation of at alkaline pH increased effect. Pre-incubation gamma-glutamyl transferase (GT) during 10 h room temperature (pH 8.2) even enhanced by factor 8 to 16 depending on strain. In accordance this finding, synthetic p-hydroxymethylphenylhydrazine (the product GT catalyzed degradation) also mutagenicity, but increase was only about 3- 6- times compared agaritine. The hypothetical ultimate metabolite agaritine, p-hydroxymethylbenzenediazonium ion, compound occurring naturally in A. highest (with approximately 300 1,000 revertants/mumol).
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sci-hub.se 参考文章(21)
Bruce Levenberg, Isolation and Structure of Agaritine, a γ-Glutamyl-substituted Arylhydrazine Derivative from Agaricaceae Journal of Biological Chemistry. ,vol. 239, pp. 2267- 2273 ,(1964) , 10.1016/S0021-9258(20)82230-3
Bela Toth, Synthetic and Naturally Occurring Hydrazines as Possible Cancer Causative Agents Cancer Research. ,vol. 35, pp. 3693- 3697 ,(1975)
O. Sterner, R. Bergman, E. Kesler, G. Magnusson, L. Nilsson, B. Wickberg, E. Zimerson, G. Zetterberg, Mutagens in larger fungi: I. Forty-eight species screened for mutagenic activity in the Salmonella/microsome assay Mutation Research\/genetic Toxicology. ,vol. 101, pp. 269- 281 ,(1982) , 10.1016/0165-1218(82)90120-3
Donald Nagel, Bela Toth, Kenneth Antonson, James Erickson, Kashinath Patil, Tumor Induction with the N′-Acetyl Derivative of 4-Hydroxymethylphenylhydrazine, a Metabolite of Agaritine of Agaricus bisporus Cancer Research. ,vol. 38, pp. 177- 180 ,(1978)
B. Toth, A. Tompa, K. Patil, Tumorigenic effect of 4-methylphenylhydrazine hydrochloride in Swiss mice. Zeitschrift für Krebsforschung. ,vol. 89, pp. 245- 252 ,(1977) , 10.1007/BF00283781
Bruce N. Ames, Joyce McCann, Edith Yamasaki, Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test Mutation Research. ,vol. 31, pp. 347- 364 ,(1975) , 10.1016/0165-1161(75)90046-1
Allan E. Ross, Donald L. Nagel, Bela Toth, Evidence for the occurrence and formation of diazonium ions in the Agaricus bisporus mushroom and its extracts. Journal of Agricultural and Food Chemistry. ,vol. 30, pp. 521- 525 ,(1982) , 10.1021/JF00111A028
J. McCann, E. Choi, E. Yamasaki, B. N. Ames, Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 5135- 5139 ,(1975) , 10.1073/PNAS.72.12.5135
Takie Yahagi, Minako Nagao, Yuko Seino, Taijiro Matsushima, Takashi Sugimura, Masashi Okada, Mutagenicities of N-nitrosamines on Salmonella. Mutation Research. ,vol. 48, pp. 121- 129 ,(1977) , 10.1016/0027-5107(77)90151-8
Eleanor G. Rogan, Betty A. Walker, Ralph Gingell, Donald L. Nagel, Bela Toth, Microbial mutagenicity of selected hydrazines. Mutation Research\/genetic Toxicology. ,vol. 102, pp. 413- 424 ,(1982) , 10.1016/0165-1218(82)90104-5