Effects of the antibiotic resistomycin on the synthesis of macromolecules.
作者： I. Haupt , U. Wähnert , Ch. Pitra , G. Löber , G. Luck
关键词: DNA 、 Transcription (biology) 、 Biology 、 Molecular biology 、 Oligonucleotide 、 Biochemistry 、 RNA polymerase 、 RNA 、 Nuclease protection assay 、 Polymerase 、 RNA-dependent RNA polymerase
摘要: Resistomycin preferentially inhibits RNA synthesis in comparison to DNA and protein intact bacterial cells. Studies with cell-free systems have shown that the antibiotic interferes synthesis, while is inhibited a much lesser extent. Detailed studies indicate an interaction of resistomycin DNA- polymerase. In case polymerase this was proved by CD measurements, whereas no DNA, RNA, homopolynucleotides could be found. One can conclude binding basis for its interference synthesis.
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