Effect of demycarosylturimycin on ribosomal peptidyltransferase from Escherichia coli.
作者： I. HAUPT , H. FRICKE , J. CERNÁ , I. RYCHLÍK
DOI: 10.7164/ANTIBIOTICS.31.610
关键词: Bacterial growth 、 Biochemistry 、 Substrate (chemistry) 、 Ribosomal RNA 、 Stereochemistry 、 Acyl group 、 Escherichia coli 、 Moiety 、 Chemistry 、 Demycarosylturimycin H
摘要: The effect of demycarosylturimycin H on bacterial growth, polypeptide synthesis and peptidyltransferase was studied. effects are compared with those intact turimycins acylated or deacylated in 4''-position mycarose. removal the acyl group 4''- position mycarose leads to a total loss inhibition acceptor substrate binding while moiety changes pattern synthesis.
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