Natural killer cell receptors: alterations and therapeutic targeting in malignancies

摘要: Numerous newly identified activating and inhibitory NK cell receptors their engagement by cognate ligands on target tumor cells regulate antitumor activity. Alterations in receptor expression signaling underlie diminished cytotoxic function. Cytokines, IFN-α, IL-2, IL-12, IL-15 IL-18, applied systemically for ex vivo activation expansion of have improved activity increasing the inducing effector molecules. Moreover, it has been recognized that classical novel pharmacological agents upregulate provide better response. Some other immunotherapeutic approaches cancer setting donor-recipient KIR/HLA mismatch evolved with aim to potentiate allogeneic hematopoietic stem transplantation lead beneficial graft vs. effect. Therefore, understanding biology is needed assist developing effectively manipulate create effective cell-based immunotherapy treatment patients.