The Right Dose: From Phase I to Clinical Practice.

摘要: To realize the full potential of promising new anticancer drugs, it is paramount importance to administer them at right dose. The aim this educational article provide several opportunities optimize drug dosing, focusing on oral targeted therapies. First, therapeutic monitoring can exposure in individual patients, if optimal concentration known. This approach particular interest regard kinase inhibitors with high interindividual pharmacokinetic variability. If related response, then potentially feasible, although clinical utility has not yet been established. Other approaches reduce variability include administration more frequent, smaller doses and under prandial conditions. However, for many labeled dose demonstrated be dose; such agents, vast majority patients may receiving excessive doses, which results toxicity. Furthermore, lower off-label both medical financial These strategies should applied from registration studies practice, goal better optimizing treatment.