Reduction in experimental pericardial adhesions using a hyaluronic acid bioabsorbable membrane.

摘要: Various materials have been suggested for pericardial closure following cardiac surgery to limit postoperative adhesion formation. Unfortunately, these devices caused difficulties with infection, calcification, and epicardial scar A bioabsorbable membrane a short in-vivo persistence time, acting as barrier formation until mesothelial healing occurs, might obviate many of problems. We examined the efficacy containing hyaluronic acid in prevention experimental adhesions; solutions shown experimentally reduce adhesions abdominal, orthopedic surgery. Eleven dogs underwent sternotomy pericardiotomy followed by 2-h protocol desiccation abrasion surfaces. In five dogs, surfaces were covered test material, closure. Six served controls. All animals resternotomy 8 weeks after surgery; intrapericardial graded on severity scale (0-4). The (mean score 1.4 +/- 0.5) had either no or filmy, avascular easily taken down blunt dissection. contrast, dense found control 3.2 0.4), frequently obscuring tissue planes anatomy. Use significantly reduced (test vs control, P < 0.001, Mann-Whitney test). conclude that reduces this canine model, use warrants further investigation.