Relationship between antioxidant capacity and oxidative stress in children with acute hepatitis A

作者: Mustafa Cemek , Semiha Dede , Fahri Bayiroğlu , Hüseyin Çaksen , Fatma Cemek

DOI: 10.3748/WJG.V12.I38.6212

关键词: Vitamin ERetinolImmunologyInternal medicineMalondialdehydeVitamin CEndocrinologyAscorbic acidLipid peroxidationBiologyHepatitis AOxidative stressGastroenterologyGeneral Medicine

摘要: AIM: To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA, an indicator oxidative stress) and nonenzymic antioxidants A. METHODS: Whole MDA reduced glutathione (GSH), serum β-carotene, retinol, vitamin E C were studied 19 (10 females, 9 males) A 29 (13 16 healthy control subjects. RESULTS: There was a statistically significant difference between patients controls for all parameters (P < 0.05). Lipid peroxidation marker significantly elevated 0.001), while retinol GSH decreased (all P 0.001) compared subjects. In addition, α-tocopherol ascorbic acid lower when age sex matched 0.05, 0.01, respectively). CONCLUSION: Our study shows that virus induces stress childern This finding could be taken into consideration improve therapeutic approach

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