Inducible expression of the signal transduction protein 14-3-3γ in injured arteries and stimulated human vascular smooth muscle cells

摘要: Abstract Although the 14-3-3 family of proteins have been shown to be key signal transduction involved in regulation cellular growth and proliferation, little has reported on their expression pathophysiological states. We hypothesized that one isoform, 14-3-3γ, would also increased vascular proliferative diseases. observed 14-3-3γ induced human coronary artery vasculopathy (CAV) as compared with arteries isolated from normal end-stage heart failure patients. is acutely expressed aortic medial smooth muscle cells experimental models arterial injury including rat cardiac allografts balloon angioplasty-injured swine arteries. In each case, protein by 3 days peaks at 7–10 post-injury. Expression this cultured (VSMC) associated cytokine-induced VSMC activation, rather than direct themselves, unique among other proteins. Potential protein–protein interactions are differentially regulated cytokine stimulation. This study indicates trauma cytokines, suggests may play an important role progression