COMPOSITIONS CONTAINING, METHODS AND USES OF ANTIBODY-TLR AGONIST CONJUGATES
作者： Kang Mingchao , Tian Feng , Knudsen Nickolas , Moon Sung-Ju , Wang Jianing
DOI:
关键词: Oxime 、 Conjugate 、 Derivative (chemistry) 、 Amino acid 、 Antibody 、 Combinatorial chemistry 、 Hydroxylamine 、 Chemistry 、 Tlr agonists
摘要: Disclosed herein are Trastuzumab-linked TLR-agonist derivative analogs that include at least one non-natural amino acid, and methods for making such acids polypeptides. The can a wide range of possible functionalities, but typically have oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed acid further modified post- translationally, effecting modifications, purifying analogs. Typically, the Trastuzumab- linked Further using analogs, including therapeutic, diagnostic, other biotechnology use.
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