Interferon-beta variants and conjugates
作者： Claus Bornaes , Kim Andersen , Poul Rasmussen , Anders Pedersen
DOI:
关键词: Interferon β 、 Conjugate 、 Chemistry 、 Cancer research 、 Combinatorial chemistry 、 Multiple sclerosis 、 Interferon beta
摘要: The present invention provides new interferon β conjugates, methods of preparing such conjugates and the use in therapy, particular for treatment multiple sclerosis.
lens.org参考文章(43)
Laura Runkel, Werner Meier, R. Blake Pepinsky, Michael Karpusas, Adrian Whitty, Kathleen Kimball, Margot Brickelmaier, Celine Muldowney, Wendy Jones, Susan E. Goelz, Structural and Functional Differences Between Glycosylated and Non-glycosylated Forms of Human Interferon-β (IFN-β) Pharmaceutical Research. ,vol. 15, pp. 641- 649 ,(1998) , 10.1023/A:1011974512425
M Kenneth Jr, Scott M LeGrand, None, The Protein Folding Problem and Tertiary Structure Prediction ,(2012)
Michel Clanet, Interferon-Beta in the Treatment of Multiple Sclerosis Clinical Drug Investigation. ,vol. 21, pp. 307- 318 ,(2001) , 10.2165/00044011-200121040-00009
Jörg Bentzien, Recombinant interferon-beta muteins ,(2000)
Alice M. Wang, Ze'ev Shaked, Oxidation-resistant interferon-beta muteins and their production; formulations containing such muteins ,(1986)
Walter Charles Dr. Fiers, DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon ,(1981)
Erwin Ludo Roggen, Arne Agerlin Olsen, Der Osten Claus Von, Polypeptide-polymer conjugates having added and/or removed attachment groups ,(1998)
Bernd Otto, Christian Schneider-Fresenius, Gero Waschütza, Recombinant human beta interferon with enhanced solubility ,(1998)
Gordon M. Ringold, Michael A. Innis, Francis P. McCormick, Human interferon-β (IFN-β) produced in Chinese hamster ovary (CHO) cells ,(1994)
Leslie David Bell, Alan George Porter, Paul Gavin Boseley, Structure and properties of modified interferons ,(1985)