Interferon-beta polymer conjugates

作者: Maoliang Wang , Amartya Basu , Karen Yang , David Ray Filpula

DOI:

关键词:

摘要: Biologically-active, interferon-beta lb-polymer conjugate compositions are disclosed. The polymer portion is preferably a polyalkylene oxide having molecular weight of at least about 12 kDa. Methods making and using the same also

参考文章(34)
Annapurna Pendri, Richard B. Greenwald, Yun H. Choe, Coumarin and related aromatic-based polymeric prodrugs ,(1999)
Claus Bornaes, Kim Andersen, Poul Rasmussen, Anders Pedersen, Interferon-beta variants and conjugates ,(2002)
Gordon M. Ringold, Michael A. Innis, Francis P. McCormick, Human interferon-β (IFN-β) produced in Chinese hamster ovary (CHO) cells ,(1994)
Isabel Zaror, Robert J. Bishop, Kenneth Crawford, Michael A. Innis, Pichia secretory leader for protein expression ,(1996)
Leo S. Lin, Shi-Da Yu Lu, David F. Mark, Human recombinant cysteine depleted interferon-β muteins ,(1984)
Lawrence S. Cousens, Patricia Tekamp-Olson, Enhanced purification and expression of insoluble recombinant proteins ,(1993)
Hayao Ueno, Masahiko Fujino, Reduction of chemically modified proteins ,(1989)