Recombinant human beta interferon with enhanced solubility

摘要: The invention relates to variants of recombinant human beta interferon and a method for the production thereof, wherein at least one following amino acids Leu (5), Phe(8), Phe(15), Leu(47), Phe(50), Leu(106), Phe(111), Leu(116), Leu(120) Phe(156) are exchanged with hydrophilic acid hydroxy group, specially serine, tyrosine or threonine, resulting in enhanced property protein surface.