Oxidation-resistant interferon-beta muteins and their production; formulations containing such muteins
作者： Alice M. Wang , Ze'ev Shaked
DOI:
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摘要: A biologically active reference (e.g. human) IFN-Beta protein is protected against oxidation by a method involving substituting conservative amino acid for each methionine residue susceptible to chloramine T or peroxide oxidation, where additional, non-susceptible residues are not so-substituted.
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