Muteins of IFN-β

摘要: A IFN-β mutein in which phe (F), tyr (Y), trp (W) or his (H) is substituted for val (V) at position 101, when numbered accordance with wild type IFN-β, DNA sequences encoding these muteins, recombinant molecules containing those operatively linked to expression control and capable of inducing an mutein, hosts transformed molecules, pharmaceutical compositions muteins methods treating viral infections, cancer tumors, undesired cell proliferation, immunomodulation.