Peripherally inserted veno-venous ultrafiltration for rapid treatment of volume overloaded patients

摘要: Background: Veno-venous ultrafiltration may benefit patients with acute or chronic circulatory volume overload. Use of conventional systems, however, be cumbersome, requiring physician placement a double-lumen central venous catheter and use dedicated dialysis technician apparatus. Methods: A simplified peripheral system including miniaturized disposable circuit was evaluated in volume-overload states. Separate intravenous catheters (16-18 G) for withdrawal return blood (blood flow ≤ 40 mL/min, ultrafiltrate 500 mL/h) were placed by nonphysician personnel upper extremity veins. Twenty-five treatments up to 8 hours performed 21 patients. Results: The primary endpoint greater than 1 L fluid removal less achieved 23 25 treatments. On average, 2611 ± 1002 mL (maximum 3,725 mL) removed per treatment (treatment period 6:43 1:47 hours:minutes). Patient weight decreased from 91.9 17.5 89.3 17.3 kg (P <.0001) after ultrafiltration. No major adverse events occurred. Conclusions: Rapid extracellular intravascular excess can safely via peripherally inserted without the need placement.