Effect of chronic consumption of metabisulphite on the integrity of the rat kidney cellular system.
作者： Musbau A Akanji , Oluremi A Olagoke , Oyelola B Oloyede , None
DOI: 10.1016/0300-483X(93)90010-P
关键词: Kidney 、 Biology 、 Endocrinology 、 Acid phosphatase 、 Toxicity 、 Enzyme 、 Internal medicine 、 Glutamate dehydrogenase 、 Renal function 、 Alkaline phosphatase 、 Lactate dehydrogenase
摘要: Abstract The effect of chronic consumption metabisulphite, a food preservative, on the integrity rat kidney cellular system was investigated. levels activities some ‘marker’ enzymes were measured both before and after administration between 1 15 doses chemical compound. Feeding metabisulphite (5 mg/kg body wt.) to rats resulted in loss alkaline phosphatase from beginning first dose. This accompanied by reduction lactate dehydrogenase activity which noticed as secondary reaction, taking place five daily doses. an increase decrease serum. An increased urinary excretion protein also obtained. Other assayed (acid glutamate activities) not significantly affected tissues urine. All these results indicated that there is damage result metabisulphite. They indicate primarily plasma membrane. proximity soluble portion cytoplasm membrane makes it site injury cell.
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sci-hub.se 参考文章(26)
Wright Pj, Plummer Dt, Leathwood Pd, Enzymes in rat urine: alkaline phosphatase. Enzymologia. ,vol. 42, pp. 317- 327 ,(1972)
David T. Plummer, An introduction to practical biochemistry ,(1971)
C. De Duve, R. Wattiaux, P. Baudhuin, Distribution of enzymes between subcellular fractions in animal tissues. Advances in enzymology and related subjects of biochemistry. ,vol. 24, pp. 291- 358 ,(1962) , 10.1002/9780470124888.CH6
Steve L. Taylor, Nancy A. Higley, Robert K. Bush, Sulfites in foods: uses, analytical methods, residues, fate, exposure assessment, metabolism, toxicity, and hypersensitivity. Advances in food research. ,vol. 30, pp. 1- 76 ,(1986) , 10.1016/S0065-2628(08)60347-X
Wolfgang P Raab, Diagnostic Value of Urinary Enzyme Determinations Clinical Chemistry. ,vol. 18, pp. 5- 25 ,(1972) , 10.1093/CLINCHEM/18.1.5
Edwin O. Ngaha, Some biochemical changes in the rat during repeated chloroquine administration. Toxicology Letters. ,vol. 10, pp. 145- 149 ,(1982) , 10.1016/0378-4274(82)90066-2
B HALLIWELL, Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: the key role of superoxide dismutase. Cell Biology International Reports. ,vol. 2, pp. 113- 128 ,(1978) , 10.1016/0309-1651(78)90032-2
Musbau A Akanji, Stella E Nlumanze, None, Alkaline phosphatase activities following repeated suramin administration in some rat tissues in relation to their functions Pharmacology & Toxicology. ,vol. 61, pp. 182- 183 ,(1987) , 10.1111/J.1600-0773.1987.TB01799.X
Peter J. Wright, David T. Plummer, The use of urinary enzyme measurements to detect renal damage caused by nephrotoxic compounds. Biochemical Pharmacology. ,vol. 23, pp. 65- 73 ,(1974) , 10.1016/0006-2952(74)90314-1
B.G. Ellis, R.G. Price, J.C. Topham, The effect of tubular damage by mercuric chloride on kidney function and some urinary enzymes in the dog. Chemico-Biological Interactions. ,vol. 7, pp. 101- 113 ,(1973) , 10.1016/0009-2797(73)90019-7