Effect of long-term losartan administration on renal haemodynamics and function in hypertensive patients.
作者： Salvatore Paterna , Gaspare Parrinello , Rosario Scaglione , Renato Costa , Antonina Bova
关键词: Renal function 、 Kidney 、 Kidney disease 、 Internal medicine 、 Renal blood flow 、 Effective renal plasma flow 、 Medicine 、 Filtration fraction 、 Endocrinology 、 Urology 、 Losartan 、 Angiotensin II
摘要: In this study the efficacy and safety of long-term losartan administration on renal haemodynamics were evaluated in mild to moderate hypertension. After a run-in period with placebo, 18 hypertensives without or cardiovascular disease allocated (50 mg/die for one year) treatment. Renal haemodynamic measurements included plasma flow (ERPF) glomerular filtration rate (GFR) by standardized radioisotope study. Effective blood (ERBF), fraction (FF), vascular resistance (RVR) also calculated. Blood pressure was monthly, whereas function detected at baseline after 6 12 months administration. Losartan induced significant (p < 0.001) decrease SBP, DBP, MBP versus values both months. addition RVR FF 0.05) seen. 1 year treatment higher than their months, but difference not significant. Our data indicated that control associated maintained treatment, these favourable effects attenuated
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