Pharmacokinetics, safety, and antihypertensive efficacy of losartan in combination with hydrochlorothiazide in hypertensive patients with renal impairment.

摘要: The pharmacokinetics and pharmacodynamics of 7 days treatment with losartan 50 mg/hydrochlorothiazide 12.5 mg were evaluated in 14 patients normal renal function 12 mild to moderate impairment. efficacy titrated 100 25 was examined 32 hypertensive impairment who treated for weeks. Safety assessed both studies by the incidence adverse experiences. After treatment, AUC losartan, E-3174, hydrochlorothiazide slightly higher impairment, but reduction blood pressure (BP) after not different between two groups. final (week 12) mean reductions trough sitting diastolic systolic BP 15.0 +/- 7.1 mmHg (p < 0.01) 20.8 16.7 0.01), respectively. There no observed increases drug-related experiences either study. Overall, combination losartan/hydrochlorothiazide effective lowering well tolerated