Mesenchymal stem cell–based therapy for nonhealing wounds: today and tomorrow

摘要: Although advancements have been made with traditional therapies, the treatment of chronic nonhealing wounds still remains a tough challenge. In past two decades, mesenchymal stem cell (MSC)-based therapy has emerged as promising therapeutic strategy for because their characteristics including self-renewal and multidirectional differentiation ability easy collection weak immunogenicity. There is growing body basic scientific studies that shed light on functional mechanism MSCs in modulating wounds. Furthermore, critical advances achieved using MSC-based preclinical animal models well clinics trials. this present review, we summarize mechanisms highlight important clinical trials MSC particular, combination transplantation tissue-engineered skin addressed new to optimize delivery efficiency potential. Additionally, current drawbacks potential further use are implied.