作者: Diana Behrens , Jana Rolff , Jens Hoffmann
DOI: 10.1007/164_2015_29
关键词: Translational research 、 Gene expression profiling 、 Pre-clinical development 、 Cancer 、 Internal medicine 、 Drug development 、 Drug discovery 、 In vivo 、 Oncology 、 Business process discovery 、 Medicine
摘要: Experimental oncology research and preclinical drug development both substantially require specific, clinically relevant in vitro vivo tumor models. The increasing knowledge about the heterogeneity of cancer requested a substantial restructuring test systems for different stages development. To be able to cope with complexity disease, larger panels patient-derived models have implemented extensively characterized. Together individual genetically engineered supported by core functions expression profiling data analysis, an integrated discovery process has been generated predictive personalized