Therapeutic Hypothesis Testing With Rodent Brain Tumor Models.

摘要: The development and application of rodent models for preclinical testing novel therapeutics approaches treating brain tumors has been a mainstay neuro-oncology research decades, is likely to remain so into the foreseeable future. These serve as an important point entry analyzing potential efficacy experimental therapies that are being considered clinical trial evaluation. Although tumor have seen substantial change, particularly since introduction genetically engineered mouse models, certain principles associated with use these therapeutic enduring, form basis this review. Here we discuss most common while directing specific attention their usefulness in evaluation therapies. include mice spontaneously or inducibly develop tumors; syngeneic which cultured cells engrafted same strain from they were derived; patient-derived xenograft human immunocompromised rodents. emphasis review directed latter.