Genetically Engineered Models Have Advantages over Xenografts for Preclinical Studies

摘要: Mouse models of human cancer are valuable tools for research. Although xenografts and genetically engineered (GEMs) possess limitations as well advantages, each system plays a significant role in preclinical testing. Tumor easy to use, relatively inexpensive, reproducible. The main drawback is that the genetics histology tumors frequently not representative respective tumor and, thus far, these have been predictive therapeutic success one would like. By contrast, GEMs histologically accurate but disadvantages heterogeneity with regard frequency, latency, growth. These reminiscent variable behavior actual tumors. Recently, shortcomings partly overcome development anatomic molecular vivo imaging techniques such magnetic resonance bioluminescence imaging. new technologies will hopefully support use trials help determine if more predicative than responses.