A possible neurochemical basis of the central stimulatory effects of pp'DDT.
作者： M. A. Matin , F. N. Jaffery , R. A. Siddiqui
DOI: 10.1111/J.1471-4159.1981.TB01692.X
关键词: Biochemistry 、 Hydroxylamine 、 Pyridoxine 、 Normal limit 、 After treatment 、 Internal medicine 、 Aminooxyacetic acid 、 Endocrinology 、 Acetylcholine 、 Neurochemical 、 Primidone 、 Chemistry
摘要: : The striatal neurochemical changes induced by pp′DDT (600 mg/kg) in mice were: an increase the concentration of free ammonia, a decrease level GABA and reduction acetylcholine. These were maximal 5 h after treatment with pp′DDT, when animals developed ‘severe’ convulsions. convulsions modified to different degrees barbiturates. Phenobarbitone protected all from pp′DDT-induced levels acetylcholine these within normal limits. Prominal reduced severity pp′DDT-treated animals. significantly lower than control values Primidone neither nor animals, was not Aminooxyacetic acid raised above abolished animals; limits Hydroxylamine produced similar but less marked effect. Pyridoxine had no effect on or pp′DDT. ammonia agents. It is likely that stimulatory effects increasing which may be involved reducing GABA, while
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