Social Stress and Psychosis Risk: Common Neurochemical Substrates?

摘要: Environmental risk factors have been implicated in the etiology of psychotic disorders, with growing evidence showing adverse effects migration, social marginalization, urbanicity, childhood trauma, defeat, and other experiences on mental health vulnerable populations. Collectively, stress may be one mechanism that could link these environmental factors. The exact mechanism(s) by which can affect brain function, particular molecular targets involved psychosis (such as dopaminergic (DA) system), is (are) not fully understood. In this review, we will discuss interplay between changes human brain; particular, highlight impact three specific neurochemical systems: DA, neuroinflammation/immune, endocannabinoid (eCB) signaling. We chosen latter two pathways based emerging linking schizophrenia to altered neuroinflammatory processes cannabis use. further identify key developmental periods interacts pathways, suggesting window(s) opportunities for novel interventions. Taken together, suggest they a role pathogenesis disease progression, possibly provide treatment options schizophrenia, perhaps even prevent it.