Microreactor for Synthesis Via Intermediates with Assembled Units Enabling Rapid Operations
作者： N. Aoki , R. Kitajima , C. Itoh , K. Mae
关键词: Total flow 、 Chemistry 、 Heat transfer 、 Selectivity 、 Analytical chemistry 、 Mixing (process engineering) 、 Heat exchanger 、 Microreactor 、 Yield (chemistry) 、 Residence time (fluid dynamics) 、 Chemical engineering
摘要: This paper describes a reactor for multistep syntheses via intermediates with improved selectivity of the desired product. is referred to as an assembled reactor. It consists mixing, residence time, and heat exchange units. Connection these units forms module single reaction. Repeated joints modules enable be used in syntheses. Mixing transfer rate were evaluated. enabled rapid mixing under total flow rates more than 30 mL/min efficiency order 10 K per 10 ms fluids temperature difference 20–40 K. was also applied synthesis bromobenzene p-bromophenyllithium gave product yield 80 %.
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