Under explored epigenetic modulators: role in glioma chemotherapy.

摘要: Patients with somatic mutations of epigenetic regulators are characterized by aberrant chromatin modification patterns. Recent mechanistic studies pairing chemical tool compounds and deep-sequencing technology have greatly broadened our understanding regulation in glioma progression underpinned alternative treatment inhibitors. However, the effect most inhibitors is condition-dependent, overall results clinical trials still not been applied to patients. There an intense need develop more potent specific as well identify population who may achieve benefits. Besides, combination therapy conventional therapeutics another strategy. In this review, we summarize well-characterized probes research translation. We also discuss target regimens various agents. a holistic sense, try provide guidance for selecting targeted pave way personalized rational therapy.