The Hypermethylation of Foxp3 Promoter Impairs the Function of Treg Cells in EAP.

作者: Jing Chen , Changsheng Zhan , Li Zhang , Ligang Zhang , Yi Liu

DOI: 10.1007/S10753-019-01030-0

关键词: MedicineDNA methylationFOXP3MethylationCancer researchIn vitroRheumatologyNOD miceIn vivoInternal medicineAdjuvant

摘要: Treg cells are crucial for maintaining immune homeostasis in CP/CPPS, but the molecular mechanisms underlying the modulation of the function of Treg in CP/CPPS remain unclear. …

参考文章(42)
Ruben D Motrich, Mariana Maccioni, Andres A Ponce, Gerardo A Gatti, Juan P Mackern Oberti, Virginia E Rivero, None, Pathogenic consequences in semen quality of an autoimmune response against the prostate gland: from animal models to human disease. Journal of Immunology. ,vol. 177, pp. 957- 967 ,(2006) , 10.4049/JIMMUNOL.177.2.957
Aras Toker, Dirk Engelbert, Garima Garg, Julia K. Polansky, Stefan Floess, Takahisa Miyao, Udo Baron, Sandra Düber, Robert Geffers, Pascal Giehr, Sonja Schallenberg, Karsten Kretschmer, Sven Olek, Jörn Walter, Siegfried Weiss, Shohei Hori, Alf Hamann, Jochen Huehn, Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus Journal of Immunology. ,vol. 190, pp. 3180- 3188 ,(2013) , 10.4049/JIMMUNOL.1203473
Maria L Breser, Ruben D Motrich, Leonardo R Sanchez, Juan P Mackern-Oberti, Virginia E Rivero, None, Expression of CXCR3 on Specific T Cells Is Essential for Homing to the Prostate Gland in an Experimental Model of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Journal of Immunology. ,vol. 190, pp. 3121- 3133 ,(2013) , 10.4049/JIMMUNOL.1202482
Sathibalan Ponniah, Ifeyinwa Arah, Richard B. Alexander, PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome. The Prostate. ,vol. 44, pp. 49- 54 ,(2000) , 10.1002/1097-0045(20000615)44:1<49::AID-PROS7>3.0.CO;2-7
J. Quentin Clemens, Male and female pelvic pain disorders--is it all in their heads? The Journal of Urology. ,vol. 179, pp. 813- 814 ,(2008) , 10.1016/J.JURO.2007.12.001
S. Yang, N. Fujikado, D. Kolodin, C. Benoist, D. Mathis, Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance Science. ,vol. 348, pp. 589- 594 ,(2015) , 10.1126/SCIENCE.AAA7017
MARY McNAUGHTON COLLINS, RANDALL S. STAFFORD, MICHAEL P. O'LEARY, MICHAEL J. BARRY, How common is prostatitis? A national survey of physician visits. The Journal of Urology. ,vol. 159, pp. 1224- 1228 ,(1998) , 10.1016/S0022-5347(01)63564-X
Yutaka Kondo, Lanlan Shen, Alfred S Cheng, Saira Ahmed, Yanis Boumber, Chantale Charo, Tadanori Yamochi, Takeshi Urano, Koichi Furukawa, Bernard Kwabi-Addo, David L Gold, Yoshitaka Sekido, Tim Hui-Ming Huang, Jean-Pierre J Issa, Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation Nature Genetics. ,vol. 40, pp. 741- 750 ,(2008) , 10.1038/NG.159
Ruben Darío Motrich, Evelyne van Etten, Femke Baeke, Clelia Maria Riera, Chantal Mathieu, Virginia Elena Rivero, Crucial Role of Interferon-γ in Experimental Autoimmune Prostatitis The Journal of Urology. ,vol. 183, pp. 1213- 1220 ,(2010) , 10.1016/J.JURO.2009.11.008
Onno J. de Boer, Jelger J. van der Meer, Peter Teeling, Chris M. van der Loos, Allard C. van der Wal, Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLOS ONE. ,vol. 2, ,(2007) , 10.1371/JOURNAL.PONE.0000779