PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome.

摘要: BACKGROUND Previous studies demonstrated that recognition of seminal plasma antigens can occur in patients with chronic prostatitis/chronic pelvic pain syndrome. This suggests an autoimmune component may contribute to symptoms some men. To determine if any the principal secretory proteins prostate could be candidate prostatitis, we examined recall proliferative response purified CD4 T cells prostatitis and normal volunteers using autologous dendritic cells. METHODS Peripheral blood mononuclear were harvested from 14 12 by density gradient centrifugation. The stimulating irradiated produced culture monocyte-enriched fractions IL-4 Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). Purified responding population. Recall proliferation assays performed, as antigens. RESULTS In detected a greater than 2-fold increase PSA compared control 5 (36%). No Prostatic Acid Phosphatase (PAP) or β-microseminoprotein was observed these patients. In volunteer donors no history genitourinary disease symptoms, above background for prostatic antigen. CONCLUSIONS The data suggest men have evidence T-cell PSA. is antigen syndrome appropriate target immunotherapy cancer. Prostate 44:49–54, 2000. © 2000 Wiley-Liss, Inc.