Antigen-Induced Eosinophilic Lung Inflammation Develops in Mice Deficient in Chemokine Eotaxin

摘要: The mechanisms that regulate the selective infiltration of eosinophils in certain allergic diseases are still poorly understood. CC chemokine eotaxin is a potent chemoattractant, highly specific for eosinophils. Recent studies have implicated plays an important role recruitment different inflammation processes. A number other chemokines, cytokines, and chemoattractants also chemotactic activities some them present high selectivity To further study inflammation, we generated mutant mice with gene disrupted replaced by Escherichia coli β-galactosidase gene. These developed normally had no histologic or hematopoietic abnormalities. Furthermore, our showed lack did not affect models induced Sephadex beads thioglycollate, as well experimental lung eosinophilia model ovalbumin aerosol challenge, even at onset inflammatory response. replacement provided useful marker to monitor activity promoter under normal conditions after antigen challenges. Immunohistochemical staining suggested endothelial cells were major sources expression.