Participation of iNKT cells in the early and late components of Tc1-mediated DNFB contact sensitivity: cooperative role of γδ-T cells.
作者： P. W. Askenase , M. Majewska-Szczepanik , S. Kerfoot , M. Szczepanik
DOI: 10.1111/J.1365-3083.2011.02522.X
关键词: Cytotoxic T cell 、 Interferon gamma 、 Adoptive cell transfer 、 Chemistry 、 Immunology 、 CD1D 、 Molecular biology 、 Immunophenotyping 、 Flow cytometry 、 Picryl chloride 、 Natural killer T cell
摘要: Prior studies of classical 24 h responses in TNP-Cl (picryl chloride) allergic contact sensitivity (CS), showed mediation by Th1 cells CBA mice, and established that elicitation requires an early 2 CS-initiating component dependent on iNKT cells, IL-4 B-1 B cells. Here, we studied the other form cytotoxic T cell (Tc1) CS DNFB sensitized BALB/c mice determined similar CS-initiation also is required. We systematically tested each step initiation pathway this model. Thus, Tc1 was significantly impaired deficient CD1d(-/-) Jα18(-/-) IL4Rα(-/-) STAT-6(-/-) pan B-cell JH(-/-) mice. Further, component, like response to TNP-Cl, elicited only 1-day after immunization, due In summary, show CS-Initiation required CS. have newly regulatory support both late components induced γδ-T assisting are involved initiating effector phases
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