The Alternative Oxidase: in vivo Regulation and Function

摘要: Abstract: This review focuses on the biochemical regulation and function of alternative oxidase in vivo. About 10 years ago, two activation mechanisms were discovered isolated mitochondria, namely by reducing sulfur bonds protein an allosteric effect pyruvate. It was proposed that plants would have a regulatory mechanism to modify activity However, more recent studies shown these may not play such important role vivo after all. Pyruvate reduction sulfide are definitely required for activity, but they do appear be regulating vivo. Despite energy wasting nature oxidase, there no obvious physiological pathway many years. is now clear can prevent production excess reactive oxygen species radicals stabilizing redox state mitochondrial ubiquinone pool, while allowing continued citric acid cycle. under conditions when NADH supply relatively high (reductant overflow), or cytochrome restrained. The might inhibited naturally occurring cyanide, nitric oxide, sulfide, concentrations CO2, low temperatures, limited phosphate supply.