Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation

摘要: Antibiotics have revolutionized the treatment of infectious disease but also rapidly selected for emergence resistant pathogens. Traditional methods antibiotic discovery failed to keep pace with evolution this resistance, which suggests that new strategies combat bacterial infections may be required. An improved understanding stress responses and in some circumstances, ability bacteria survive therapy either by transiently tolerating antibiotics or evolving resistance requires specific biochemical processes themselves subject intervention. Inhibiting these prolong efficacy current provide an alternative escalating arms race between resistance. Though approaches are not clinically validated will certainly face their own set challenges, potential protect our ever-shrinking arsenal merits investigation. This Review summarizes early efforts toward goal.