Drugs for bad bugs: confronting the challenges of antibacterial discovery
作者： David J. Payne , Michael N. Gwynn , David J. Holmes , David L. Pompliano
DOI: 10.1038/NRD2201
关键词:
摘要: The sequencing of the first complete bacterial genome in 1995 heralded a new era of hope for antibacterial drug discoverers, who now had the tools to search entire genomes for new antibacterial targets. Several companies, including GlaxoSmithKline, moved back into the antibacterials area and embraced a genomics-derived, target-based approach to screen for new classes of drugs with novel modes of action. Here, we share our experience of evaluating more than 300 genes and 70 high-throughput screening campaigns over a …
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