Microelectrophoretic behaviour of gelatin and acacia complex coacervates and indomethacin microcapsules

作者: D.J. Burgess , J.E. Carless

DOI: 10.1016/0378-5173(86)90180-8

关键词: AdsorptionColloidAcaciaDosage formCoacervateChromatographyElectrophoresisGelatinPharmaceutical technologyChemistryPharmaceutical Science

摘要: Abstract The electrophoretic behaviour of gelatin/acacia and gelatin/gelatin complex coacervates is identical to that equivalent mixtures these polyions adsorbed onto a colloidal carrier. Encapsulated indomethacin particles, affected the microcapsules, but had no such effect on microcapsules.

参考文章(8)
Motoharu Shiba, Yasuaki Kawano, Suiichi Tomioka, Masumi Koishi, Tamotsu Kondo, Studies on Microcapsules. XI. Electrophoretic Behavior of Polyphthalamide Microcapsules Containing Aqueous Solution of Bovine Serum Albumin Bulletin of the Chemical Society of Japan. ,vol. 44, pp. 2911- 2915 ,(1971) , 10.1246/BCSJ.44.2911
D.J. Burgess, J.E. Carless, Manufacture of gelatin/gelatin coacervate microcapsules International Journal of Pharmaceutics. ,vol. 27, pp. 61- 70 ,(1985) , 10.1016/0378-5173(85)90185-1
Louis A. Luzzi, Robert J. Gerraughty, Effect of additives and formulation techniques on controlled release of drugs from microcapsules Journal of Pharmaceutical Sciences. ,vol. 56, pp. 1174- 1177 ,(1967) , 10.1002/JPS.2600560927
A.M Kragh, W.B Langston, The flocculation of quartz and other suspensions with gelatine Journal of Colloid Science. ,vol. 17, pp. 101- 123 ,(1962) , 10.1016/0095-8522(62)90002-8
D.J. Burgess, J.E. Carless, Microelectrophoretic studies of gelatin and acacia for the prediction of complex coacervation Journal of Colloid and Interface Science. ,vol. 98, pp. 1- 8 ,(1984) , 10.1016/0021-9797(84)90472-7
Ian W. Kellaway, Naji M. Najib, The effect of hydrophilic polymers on the electrophoretc mobility of suspended particles International Journal of Pharmaceutics. ,vol. 7, pp. 285- 292 ,(1981) , 10.1016/0378-5173(81)90054-5
H. Takenaka, Y. Kawashimax, S.Y. Lin, Electrophoretic Properties of Sulfamethoxazole Microcapsules and Gelatin-Acacia Coacervates Journal of Pharmaceutical Sciences. ,vol. 70, pp. 302- 305 ,(1981) , 10.1002/JPS.2600700320
A W Kenchington, A G Ward, J W Janus, A rapid method for the determination of the isoelectric point of gelatin using mixed bed deionization. Research; a journal of science and its applications. ,vol. 4, pp. 247- 248 ,(1951)