Outcomes and prognostic factors in adolescents and young adults with ALL treated with a modified BFM-90 protocol.
作者： Bhausaheb Bagal , Anant Gokarn , Prashant Tembhare , Navin Khattry , Manju Sengar
DOI: 10.1182/BLOODADVANCES.2020003526
关键词: Protocol (science) 、 Internal medicine 、 Medical record 、 Young adult 、 Regimen 、 Increased risk 、 Minimal residual disease 、 MEDLINE 、 Acute lymphocytic leukemia 、 Medicine
摘要: The use of pediatrics-inspired protocols in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) results superior survival compared with the protocols. Pediatrics-inspired carry an increased risk toxicity treatment-related mortality low resource settings, which can offset potential benefits. We studied outcomes prognostic factors treatment AYA ALL a regimen. retrieved data regarding demographics, investigations, details, toxicities from electronic medical records patients diagnosed 15- to 25-year-old age group who were initiated on modified Berlin-Frankfurt-Munster 90 (BFM-90) protocol between January 2013 December 2016 at Tata Memorial Centre. A total 349 treated BFM-90 protocol. this resulted 3-year event-free (EFS) overall (OS) 59.4% 61.8%, respectively. Only 15 underwent allogeneic stem cell transplant. Minimal residual disease (MRD) persistence postinduction emerged as only factor predictive poor outcomes. is effective safe regimen for OS EFS comparable published literature.
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