Process for the preparation of acetic acid derivatives

作者: Charles Pigerol , Michel Chignac , Claude Grain

DOI:

关键词: HydroxideSodiumAcetic acidAcetamideSalt (chemistry)Aqueous solutionHydrolysisInorganic chemistryChemistryPotassium hydroxide

摘要: Process for the preparation of di-n-propyl acetic acid formula: ##STR1## and its non-toxic alkali alkaline earth metal salts whereby in a single stage, sodium n-propylate n-propanol medium is added to reaction formed cyanacetic ester general ##STR2## which R represents an alkyl radical having from 1 4 carbon atoms, n-propyl bromide or iodide, alkylation taking place under reflux, crude obtained saponified with 10 20% solution potassium hydroxide, salt thus acidified strong acid, give decarboxylated by heating at temperature between 140° 190° C, provide acetonitrile, acetonitrile hydrolysed means aqueous 75 80% sulphuric 80°-140° C acetamide, hydrolyzed 75-80% 40°-80° presence nitrite, caused react, if so desired, hydroxide oxide order obtain corresponding salt.

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