Pentanoic acid derivatives

摘要: Formula (I) compounds: wherein R1 is alkyl substituted by fluorine(s); R2 hydroxy, alkoxy, alkoxy phenyl, NR3R4, in which R3, R4 (i) hydrogen, (ii) alkyl, (iii) (iv) phenyl or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) subsituted (vii) the bonded to R3 and R4, taken together a saturated amino acid residue; non-toxic salts addition thereof. Also, (X) n 0 1, R11 hydrogen chlorine, R5 R7—CH2— R8, R11, alkylidene; R6 NR9R10, R9, R10 phenyl-substituted R9 R10, residue, R7 F—(CH2)m— F3C—CH2—, subsstituted cycloalkyl, phenoxy; R8 alkenyl, alkylthio, phenoxy. Non-toxic thereof are useful prevent and/or treat neurodegenerative disease (e.g., Alzheimer's) neuronal dysfunction stroke traumatic injury Multiple sclerosis).