Basal linear deposit in the human macula.

摘要: We used electron microscopy and immunohistochemistry to study the macular regions of nine enucleated elderly human eyes document various abnormalities present in so-called basal linear deposit. These changes include bush-like strands electron-dense material, which project from basement membrane retinal pigment epithelium, deposition wide-banded collagen, vesiculoid elements, membrane-bound structures occasional melanin granules. Fibronectin was also identified deposit Bruch's membrane, but mucopolysaccharides could not be demonstrated. The presence electron-empty spaces suggests a disturbance water permeability. Our studies showed neovascularisation beneath epithelium locations where abundant, as well erosion by macrophages endothelial cell processes. findings suggest that is an important precursor neovascularisation. Possible pathogenetic mechanisms are discussed.