Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors

摘要: Hematopoietic stem cell (HSC) transplantation (HSCT) is now increasingly used to treat a wide range of hematological malignancies as well certain nonmalignant diseases such bone marrow failure and immunodeficiency syndromes, metabolic disorders, autoimmune [1]. In addition, HSC have been investigated for the treatment ischemic heart disease stroke, with some encouraging results [2, 3]. The use mobilized peripheral blood has largely overtaken that collected from pelvic due two significant advantages former over latter. Firstly, collection less invasive, requiring only venous access leukapheresis, opposed need general anesthesia surgical procedure harvest. Secondly, there higher yield hematopoietic progenitor cells (as measured by CD34+ counts) collections than harvests. As consequence, reduction in duration both severe neutropenia thrombocytopenia after (PBSCT) compared transplantation, corresponding reductions toxicity incidence serious complications [4]. Peripheral (PBSC) are almost exclusively autologous HSCT, also majority normal donors allogeneic HSCT.