Preparation and controlled drug delivery applications of mesoporous silica polymer nanocomposites through the visible light induced surface-initiated ATRP

摘要: Abstract The mesoporous materials with large pore size, high specific surface area and thermal stability have been widely utilized in a variety of fields ranging from environmental remediation to separation biomedicine. However, modification these silica nanomaterials is required endow novel properties achieve better performance for most applications. In this work, new method has established nanoparticles (MSNs) that relied on the visible light induced atom transfer radical polymerization (ATRP). procedure, copolymers composited itaconic acid (IA) poly(ethylene glycol)methyl acrylate (PEGMA) were grafted MSNs using IA PEGMA as monomers 10-Phenylphenothiazine(PTH) organic catalyst. successful preparation final polymer nanocomposites (named MSNs-NH 2 -poly(IA- co -PEGMA)) evidenced by series characterization techniques. More importantly, anticancer agent cisplatin can be effectively loaded -PEGMA) controlled release it drug-loading composites pH responsive behavior. As compared conventional ATRP, surface-initiated ATRP could also various under rather benign conditions (e.g. absent transition metal ions, low temperature short time). Taken together, we developed promising strategy fabrication multifunctional co- PEGMA) great potential biomedical