Anticancer Activity of Atractylodes lancea (Thunb.) DC in a Hamster Model and Application of PET-CT for Early Detection and Monitoring Progression of Cholangiocarcinoma.
作者： Tullayakorn Plengsuriyakarn , Naoki Matsuda , Juntra Karbwang , Vithoon Viyanant , Kenji Hirayama
DOI: 10.7314/APJCP.2015.16.15.6279
关键词: Opisthorchis viverrini 、 Medicine 、 Pathology 、 Atractylodes lancea 、 Toxicity 、 Cancer 、 Atractylodes 、 Hamster 、 Mesocricetus 、 Pharmacology 、 Phytotherapy
摘要: Opisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) is an important cancer in the Great Mekong region, particularly Thailand. Limitations of treatment options and lack effective diagnostic tool for early detection CCA are major concerns control this type cancer. The aim study was to investigate anti-CCA activity ethanolic extract Atractylodes lancea (Thunb.) DC., applicability positron emission tomography-computed tomography (PET-CT) as a monitoring progression (OV)/dimethylnitrosamine (DMN)-induced hamsters. Male Syrian hamsters were used toxicity tests evaluation. Development induced by initial feeding 50 metacercariae OV, followed drinking water containing 12.5 ppm DMN A. DC. administered orally 30 days. PET-CT performed every 4 weeks after initiation using 18F-fluorodeoxyglucose ( 18 F-FDG). Results from present suggest that rhizome exhibited promising safety profile OV/DMN-induced hamster model. To successfully apply tumor development progression, modification radiolabeling approach required improve its specificity cells.
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