The Contribution of Growth Hormone to Mammary Neoplasia
作者： Jo K Perry , Kumarasamypet M Mohankumar , B Starling Emerald , Hichem C Mertani , Peter E Lobie
DOI: 10.1007/S10911-008-9070-Z
关键词: Oncogene 、 Internal medicine 、 Endocrinology 、 Cancer research 、 Cancer 、 Mammary gland 、 Breast cancer 、 Autocrine signalling 、 Biology 、 Therapeutic approach 、 Signal transduction 、 Growth hormone
摘要: While the effects of growth hormone (GH) on longitudinal are well established, observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in development and a wide range malignancies including breast cancer. Recently autocrine human been demonstrated be an orthotopically expressed oncogene for mammary gland. This review will highlight recent evidence linking carcinoma discuss GH-antagonism as potential therapeutic approach treatment
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