Telomeres: Cancer to Human Aging

作者: Sheila A Stewart , Robert A. Weinberg

DOI: 10.1146/ANNUREV.CELLBIO.22.010305.104518

关键词: CancerTelomeraseCarcinogenesisPhenotypeBiologyCellFunction (biology)SenescenceTelomereCell biologyGeneticsDevelopmental biology

摘要: The cell phenotypes of senescence and crisis operate to circumscribe the proliferative potential of mammalian cells, suggesting that both are capable of operating in vivo to …

参考文章(144)
Madalena Tarsounas, Purificacıon Munoz, Andreas Claas, Phillip G Smiraldo, Douglas L Pittman, Marıa A Blasco, Stephen C West, None, Telomere Maintenance Requires the RAD51D Recombination/Repair Protein Cell. ,vol. 117, pp. 337- 347 ,(2004) , 10.1016/S0092-8674(04)00337-X
Carmela P. Morales, Shawn E. Holt, Michel Ouellette, Kiran J. Kaur, Ying Yan, Kathleen S. Wilson, Michael A. White, Woodring E. Wright, Jerry W. Shay, Absence of cancer-associated changes in human fibroblasts immortalized with telomerase Nature Genetics. ,vol. 21, pp. 115- 118 ,(1999) , 10.1038/5063
Tom Vulliamy, Anna Marrone, Richard Szydlo, Amanda Walne, Philip J Mason, Inderjeet Dokal, Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC Nature Genetics. ,vol. 36, pp. 447- 449 ,(2004) , 10.1038/NG1346
Silvia Espejel, Sonia Franco, Sandra Rodríguez‐Perales, Simon D Bouffler, Juan C Cigudosa, María A Blasco, None, Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres The EMBO Journal. ,vol. 21, pp. 2207- 2219 ,(2002) , 10.1093/EMBOJ/21.9.2207
Utz Herbig, Wendy A Jobling, Benjamin P.C Chen, David J Chen, John M Sedivy, Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a Molecular Cell. ,vol. 14, pp. 501- 513 ,(2004) , 10.1016/S1097-2765(04)00256-4
Purificación Munoz, Raquel Blanco, Juana M Flores, María A Blasco, None, XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer Nature Genetics. ,vol. 37, pp. 1063- 1071 ,(2005) , 10.1038/NG1633
Jerry W. Shay, Woodring E. Wright, Harold Werbin, Defining the molecular mechanisms of human cell immortalization Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. ,vol. 1072, pp. 1- 7 ,(1991) , 10.1016/0304-419X(91)90003-4
William Chang, Jasmin N Dynek, Susan Smith, TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres Genes & Development. ,vol. 17, pp. 1328- 1333 ,(2003) , 10.1101/GAD.1077103
J.W. Shay, S. Bacchetti, A survey of telomerase activity in human cancer European Journal of Cancer. ,vol. 33, pp. 787- 791 ,(1997) , 10.1016/S0959-8049(97)00062-2
Jack D Griffith, Laurey Comeau, Soraya Rosenfield, Rachel M Stansel, Alessandro Bianchi, Heidi Moss, Titia de Lange, Mammalian telomeres end in a large duplex loop. Cell. ,vol. 97, pp. 503- 514 ,(1999) , 10.1016/S0092-8674(00)80760-6