TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres
作者： William Chang , Jasmin N Dynek , Susan Smith
DOI: 10.1101/GAD.1077103
关键词:
摘要: … Here, we show that tankyrase 1 induces proteasome-mediated degradation of TRF1. We demonstrate that TRF1 is ubiquitinated in vivo and in vitro. We present evidence to suggest that …
genesdev.org参考文章(29)
Titia de Lange, Protection of mammalian telomeres Oncogene. ,vol. 21, pp. 532- 540 ,(2002) , 10.1038/SJ.ONC.1205080
C.M. Counter, A.A. Avilion, C.E. LeFeuvre, N.G. Stewart, C.W. Greider, C.B. Harley, S. Bacchetti, Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. The EMBO Journal. ,vol. 11, pp. 1921- 1929 ,(1992) , 10.1002/J.1460-2075.1992.TB05245.X
Edward T Kipreos, Michele Pagano, The F-box protein family. Genome Biology. ,vol. 1, pp. 1- 7 ,(2000) , 10.1186/GB-2000-1-5-REVIEWS3002
S.K. Evans, V. Lundblad, Positive and negative regulation of telomerase access to the telomere Journal of Cell Science. ,vol. 113, pp. 3357- 3364 ,(2000)
Laetitia Davidovic, Momchil Vodenicharov, El Bachir Affar, Guy G. Poirier, Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Experimental Cell Research. ,vol. 268, pp. 7- 13 ,(2001) , 10.1006/EXCR.2001.5263
N. Kim, M. Piatyszek, K. Prowse, C. Harley, M. West, P. Ho, G. Coviello, W. Wright, S. Weinrich, J. Shay, Specific association of human telomerase activity with immortal cells and cancer Science. ,vol. 266, pp. 2011- 2015 ,(1994) , 10.1126/SCIENCE.7605428
Mathias Treier, Lena M. Staszewski, Dirk Bohmann, Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell. ,vol. 78, pp. 787- 798 ,(1994) , 10.1016/S0092-8674(94)90502-9
Hiroyuki Seimiya, Susan Smith, The Telomeric Poly(ADP-ribose) Polymerase, Tankyrase 1, Contains Multiple Binding Sites for Telomeric Repeat Binding Factor 1 (TRF1) and a Novel Acceptor, 182-kDa Tankyrase-binding Protein (TAB182) Journal of Biological Chemistry. ,vol. 277, pp. 14116- 14126 ,(2002) , 10.1074/JBC.M112266200
Jack D Griffith, Laurey Comeau, Soraya Rosenfield, Rachel M Stansel, Alessandro Bianchi, Heidi Moss, Titia de Lange, Mammalian telomeres end in a large duplex loop. Cell. ,vol. 97, pp. 503- 514 ,(1999) , 10.1016/S0092-8674(00)80760-6
Thomas Bilaud, Christine Brun, Katia Ancelin, Catherine Elaine Koering, Thierry Laroche, Eric Gilson, Telomeric localization of TRF2, a novel human telobox protein Nature Genetics. ,vol. 17, pp. 236- 239 ,(1997) , 10.1038/NG1097-236