Recombinant microorganisms having modified production of alcohols and acids

摘要: Recombinant acetogenic Clostridia are engineered to modulate production of aliphatic C 2 -C 6 alcohols and organic acids from synthetic gases. One aspect the invention provides a method producing an alcohol using Clostridium micro-organism having at least one genetic modification that reduces or eliminates carboxylic acid by modified organism. Another more modifications cause increased enzyme activity carbon monoxide dehydrogenase, aldehyde ferredoxin oxidoreductase, NADPH-dependent dehydrogenase. Yet another C2-C6 micro-organisms have been genetically increase formation decrease corresponding acid.