Phase Ib study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer

作者: David M. O'Malley , Ursula A. Matulonis , Michael J. Birrer , Cesar M. Castro , Lucy Gilbert

DOI: 10.1016/J.YGYNO.2020.01.037

关键词: Antibody-drug conjugateCarcinomaOncologyChemotherapyInternal medicineOvarian cancerAdverse effectProgression-free survivalMonoclonalMedicineBevacizumab

摘要: … The first targeted agent indicated for use in EOC was the angiogenesis … target of interest in EOC is folate receptor alpha (FRα) [11], a transmembrane protein involved in cellular folate …

参考文章(39)
Fabio A.B. Schutz, Denis L.F. Jardim, Youjin Je, Toni K. Choueiri, Haematologic toxicities associated with the addition of bevacizumab in cancer patients European Journal of Cancer. ,vol. 47, pp. 1161- 1174 ,(2011) , 10.1016/J.EJCA.2011.03.005
E.A. Eisenhauer, P. Therasse, J. Bogaerts, L.H. Schwartz, D. Sargent, R. Ford, J. Dancey, S. Arbuck, S. Gwyther, M. Mooney, L. Rubinstein, L. Shankar, L. Dodd, R. Kaplan, D. Lacombe, J. Verweij, New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) European Journal of Cancer. ,vol. 45, pp. 228- 247 ,(2009) , 10.1016/J.EJCA.2008.10.026
Ignace B. Vergote, Christian Marth, Robert L. Coleman, Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications Cancer and Metastasis Reviews. ,vol. 34, pp. 41- 52 ,(2015) , 10.1007/S10555-014-9539-8
Alison Davis, Anna V. Tinker, Michael Friedlander, “Platinum resistant” ovarian cancer: What is it, who to treat and how to measure benefit? Gynecologic Oncology. ,vol. 133, pp. 624- 631 ,(2014) , 10.1016/J.YGYNO.2014.02.038
Olga Ab, Kathleen R. Whiteman, Laura M. Bartle, Xiuxia Sun, Rajeeva Singh, Daniel Tavares, Alyssa LaBelle, Gillian Payne, Robert J. Lutz, Jan Pinkas, Victor S. Goldmacher, Thomas Chittenden, John M. Lambert, IMGN853, a Folate Receptor-α (FRα)–Targeting Antibody–Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors Molecular Cancer Therapeutics. ,vol. 14, pp. 1605- 1613 ,(2015) , 10.1158/1535-7163.MCT-14-1095
Claudia Marchetti, Margherita Giorgini, Caterina De Medici, Innocenza Palaia, Roberta Iadarola, Laura Vertechy, Ludovico Muzii, Pierluigi Benedetti Panici, Lavinia Domenici, Violante Di Donato, Federica Tomao, Targeted drug delivery via folate receptors in recurrent ovarian cancer: A review OncoTargets and Therapy. ,vol. 7, pp. 1223- 1236 ,(2014) , 10.2147/OTT.S40947
Amit M Oza, Adrian D Cook, Jacobus Pfisterer, Andrew Embleton, Jonathan A Ledermann, Eric Pujade-Lauraine, Gunnar Kristensen, Mark S Carey, Philip Beale, Andrés Cervantes, Tjoung-Won Park-Simon, Gordon Rustin, Florence Joly, Mansoor R Mirza, Marie Plante, Michael Quinn, Andrés Poveda, Gordon C Jayson, Dan Stark, Ann Marie Swart, Laura Farrelly, Richard Kaplan, Mahesh K B Parmar, Timothy J Perren, Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial The Lancet Oncology. ,vol. 16, pp. 928- 936 ,(2015) , 10.1016/S1470-2045(15)00086-8
Mary Ann Jordan, Emin Oroudjev, Manu Lopus, Leslie Wilson, Charlene Audette, Carmela Provenzano, Hans Erickson, Yelena Kovtun, Ravi Chari, Maytansinoid-Antibody Conjugates Induce Mitotic Arrest by Suppressing Microtubule Dynamic Instability Molecular Cancer Therapeutics. ,vol. 9, pp. 2700- 2713 ,(2010) , 10.1158/1535-7163.MCT-10-0645
Jonathan A. Ledermann, Christian Marth, Mark S. Carey, Michael Birrer, David D.L. Bowtell, Stan Kaye, Iain McNeish, Amit Oza, Giovanni Scambia, Gordon Rustin, Frederick B. Stehman, David Gershenson, Gillian Thomas, Els Berns, Antonio Casado, Nelleke Ottevanger, Felix Hilpert, Byoung-Gie Kim, Aikou Okamoto, Monica Bacon, Henry Kitchener, Gavin C.E. Stuart, Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer International Journal of Gynecological Cancer. ,vol. 21, pp. 763- 770 ,(2011) , 10.1097/IGC.0B013E31821B2669