Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association.
作者： Vincent L Biron , Hadi Seikaly , David W J Côté
DOI:
关键词: Medicine 、 Oncology 、 Proportional hazards model 、 Cervix 、 Cancer 、 Internal medicine 、 Coinfection 、 Oropharyngeal squamous cell carcinoma 、 Sex organ 、 Incidence (epidemiology) 、 Cervical cancer
摘要: OBJECTIVE Human papillomavirus (HPV) is a well-established etiologic factor in oropharyngeal squamous cell carcinoma (OPSCC). The objective of this study was to evaluate the association between OPSCC and HPV-related cancerous lesions cervix. METHODS Demographic, survival, pathologic data on all female patients diagnosed with Alberta 1998 2008 were collected. A review pathology reports these undertaken identify Standardized incidence ratios (SIRs) cervical cancer calculated using control obtained from provincial surveillance. Overall disease-specific survival only versus Kaplan-Meier Cox regression models. RESULTS Our results show significantly elevated overall women comparison population (SIR 29.4, 95% CI 12.05-74.98). Patients also had improved no history cancer. CONCLUSIONS Women have risk developing genital cancers, which suggests frequent HPV coinfection tissues patient population. an as previously shown HPV-associated OPSCC.
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