Metachronous Second Primary Malignancies after Head and Neck Cancer in a Korean Cohort (1993-2010)

摘要: Second primary malignancy (SPM) is the major long-term cause of patient mortality with head and neck squamous cell carcinoma (HNSCC). As incidence high-risk human papillomavirus (HPV)-related HNSCC increasing globally, we analyzed patterns SPM occurrence, effect index tumor site along attributes to HPV, on survival in South Korean patients cancer (HNC). Data were retrieved from Korea Central Cancer Registry, a nationwide population-based registry, 1993 2010. Standardized ratios compared between sites, particularly oropharyngeal vs. non-oropharyngeal sites. After adjustment for competing risks, 3- 5-year rates calculated using cumulative function. The effects occurrence overall (OS) then analyzed. significantly lower HPV-attributable sites than such as larynx hypopharynx (p<0.001). also oral cavity first SPMs typically occurred esophagus, lungs neck. Uterine cervical cancers more frequently after women. 10-year OS 57.8 45.7% all HNC patients, respectively. was poor (5-year, 31.8%; 10-year, 20.8%) 68.4%; 41.2%). esophagus lung/bronchus showed worse localized patient, affected risk distribution. 5- deteriorated lungs. Further optimization follow-up strategies effective surveillance SPM, lungs, warranted.