Interventions for Neurocognitive Dysfunction
作者： Jacqueline Ellero , Michal Lubomski , Bruce Brew , None
DOI: 10.1007/S11904-017-0346-Z
关键词: Dementia 、 Neurocognitive 、 Psychological intervention 、 Human immunodeficiency virus (HIV) 、 Neurofilament light 、 Medicine 、 Intensive care medicine 、 Neuroimaging 、 Neurocognitive Dysfunction 、 Psychiatry 、 Neurotoxicity
摘要: This study aimed to evaluate current barriers HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last 3 years. Optimal anti-retroviral therapy (ART) poses challenges minimise neurotoxicity, whilst ensuring blood-brain barrier penetration minimising risk of cerebrovascular disease. CSF biomarkers, BCL11B neurofilament light chain may be implicated neuroinflammatory cascade leading cognitive impairment. Diagnostic imaging diffusion tensor resting-state fMRI show promise in future diagnosis monitoring HAND. The introduction ART has resulted dramatic decline HIV-associated dementia. Despite this reduction, milder forms disorder (HAND) are still prevalent clinically significant. central nervous system (CNS) been recognised as probable reservoir sanctuary HIV, representing significant management interventions.
nd.edu.au
springer.com
core.ac.uk
sci-hub.se 参考文章(98)
Kenneth J. Colodner, Rachel A. Montana, Douglas C. Anthony, Rebecca D. Folkerth, Umberto De Girolami, Mel B. Feany, Proliferative potential of human astrocytes. Journal of Neuropathology and Experimental Neurology. ,vol. 64, pp. 163- 169 ,(2005) , 10.1093/JNEN/64.2.163
Luke F Chen, Jennifer Hoy, Sharon R Lewin, Ten years of highly active antiretroviral therapy for HIV infection. The Medical Journal of Australia. ,vol. 186, pp. 146- 151 ,(2007) , 10.5694/J.1326-5377.2007.TB00839.X
François Raffi, Clotilde Allavena, Christophe Michau, Anne Chiffoleau, Gwenael Le Moal, Neuropsychiatric adverse events after switching from an antiretroviral regimen containing efavirenz without tenofovir to an efavirenz regimen containing tenofovir: a report of nine cases. Antiviral Therapy. ,vol. 11, pp. 263- 265 ,(2006)
L Ene, D Duiculescu, S M Ruta, How much do antiretroviral drugs penetrate into the central nervous system Journal of medicine and life. ,vol. 4, pp. 432- 439 ,(2011)
Qing Ma, , Florin Vaida, Jenna Wong, Chelsea A. Sanders, Yu-ting Kao, David Croteau, David B. Clifford, Ann C. Collier, Benjamin B. Gelman, Christina M. Marra, Justin C. McArthur, Susan Morgello, David M. Simpson, Robert K. Heaton, Igor Grant, Scott L. Letendre, Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients Journal of NeuroVirology. ,vol. 22, pp. 170- 178 ,(2016) , 10.1007/S13365-015-0382-7
L R Gray, D Cowley, C Welsh, H K Lu, B J Brew, S R Lewin, S L Wesselingh, P R Gorry, M J Churchill, CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies Molecular Psychiatry. ,vol. 21, pp. 574- 584 ,(2016) , 10.1038/MP.2015.111
Richard M. Rutstein, Pearl Samson, Terry Fenton, Courtney V. Fletcher, Jennifer J. Kiser, Lynne M. Mofenson, Elizabeth Smith, Bobbie Graham, Marina Mathew, Grace Aldrovani, Long-term Safety and Efficacy of Atazanavir-based Therapy in HIV-infected Infants, Children and Adolescents The Pediatric Infectious Disease Journal. ,vol. 34, pp. 162- 167 ,(2015) , 10.1097/INF.0000000000000538
Evelyn Eisele, Robert F. Siliciano, Redefining the Viral Reservoirs that Prevent HIV-1 Eradication Immunity. ,vol. 37, pp. 377- 388 ,(2012) , 10.1016/J.IMMUNI.2012.08.010
G. Schifitto, C. T. Yiannoutsos, T. Ernst, B. A. Navia, A. Nath, N. Sacktor, C. Anderson, C. M. Marra, D. B. Clifford, , Selegiline and oxidative stress in HIV-associated cognitive impairment Neurology. ,vol. 73, pp. 1975- 1981 ,(2009) , 10.1212/WNL.0B013E3181C51A48
EJ Wright, B Grund, K Robertson, BJ Brew, Mollie Roediger, MP Bain, F Drummond, MJ Vjecha, Jennifer Hoy, C Miller, AC Penalva de Oliveira, W Pumpradit, JC Shlay, W El-Sadr, RW Price, Cardiovascular risk factors associated with lower baseline cognitive performance in HIV-positive persons. Neurology. ,vol. 75, pp. 864- 873 ,(2010) , 10.1212/WNL.0B013E3181F11BD8